Chromosomal Instability and IL6-Mediated Inflammatory Signaling in Human Lymphoma Cells

Abstract

Chromosomal Instability (CIN) is a hallmark of cancer that significantly impacts tumor evolution and prognosis in lymphomas. This study investigates the relationship between CIN and inflammatory signaling, particularly the IL6 pathway, in human lymphoma cell lines. Genomic analysis revealed diverse mutational landscapes across cell lines, reflecting varying degrees of genomic instability. qPCR analysis demonstrated consistent upregulation of IL6 expression upon Vincristine treatment across all tested cell lines. IncuCyte analysis of cell viability after treatment with the CIN-inducing agent BAY1217389 revealed dose-dependent effects, with certain levels of CIN potentially enhancing cell growth. These findings suggest that CIN activates IL6-mediated inflammatory signaling in lymphoma cells, contributing to a pro-tumor microenvironment and potentially modulating therapeutic outcomes.