Cinnamomum cassia and Origanum compactum Essential Oils as Antifungal Candidates for the Treatment of Aspergillosis
The painting on the cover, created using mixed media — oil and digital — depicts this journal’s home campus of McGill University at the foot of Montréal’s Mount Royal. The city-scape, illuminated by the blinding accretion disc of a black hole in the night sky, brings these elusive and distant bodies within reach of scientific and creative minds alike.


Aspergillus oryzae
Origanum compactum
Cinnamomum cassia
Essential oils

How to Cite

Leclercq, M., Commenge, I., Bouriot, M., Crusset, F., Gonzalez, P., Grimaud, J., Yates, F., Sarfati-Bert, J., & Saint-Pol, A. (2024). Cinnamomum cassia and Origanum compactum Essential Oils as Antifungal Candidates for the Treatment of Aspergillosis. McGill Science Undergraduate Research Journal, 19(1), 27–32.


Aspergillosis is a disease that usually affects the respiratory system. While most patients develop mild symptoms, aspergillosis can become a serious health threat in immunocompromised populations and patients with pre-existing respiratory conditions. Aspergillosis is caused by fungi of the Aspergillus genus. Existing treatments include drugs such as azoles, ergosterol interfering agents (Amphotericin B), and echinocandins (Caspofungin), which usually come with various drawbacks. Numerous studies have shown the antifungal properties of certain essential oils (EOs), which represent potential alternative treatments against fungal infections. Here, we screened the antifungal properties of five EOs against Aspergillus oryzae: Melaleuca alternifolia, Mentha x piperita, Thymus zygis, Origanum compactum, and Cinnamomum cassia. Of the five EOs, two demonstrated antifungal activity: Origanum compactum acted as a fungistatic, while Cinnamomum cassia showed both fungistatic and fungicidal effects against A. oryzae. Therefore, both EOs represent potential alternative treatments against Aspergillosis.
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Copyright (c) 2024 Manon Leclercq, Isciane Commenge, Marylou Bouriot, Floricia Crusset, Patrick Gonzalez, Julien Grimaud, Frank Yates, Jacqueline Sarfati-Bert, Agnès Saint-Pol


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